Three-Component Ruthenium-Catalyzed meta-C-H Alkylation of Phenol Derivatives was written by Luan, Yu-Yong;Gou, Xue-Ya;Shi, Wei-Yu;Liu, Hong-Chao;Chen, Xi;Liang, Yong-Min. And the article was included in Organic Letters in 2022.SDS of cas: 4783-68-0 This article mentions the following:
Herein, synthesis of phenyl-(pyrimidinyloxyphenyl)butanoates I [R1 = H, Me, Cl, etc.; R2 = H, Me, F, etc; R3 = Me, F; R4 = Ph, 4-FC6H4, 4-BrC6H4, etc.; R2 = R3 = Me, F; R5 = OEt, piperidin-1-yl, N(n-Bu)2] via three-component ruthenium catalyzed C-H alkylation of phenoxypyrimidines and vinylbenzene and ethyl-bromo-difluoroacetates/alkyl bromides was reported. This strategy exhibited good substrates suitability and functional group tolerance with various phenol derivatives, which provided a synthetic potential drug approach. Mechanistic studies showed that a radical process might be involved in this process. In addition, the meta alkylated phenol was obtained by further removal of the directing group. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0SDS of cas: 4783-68-0).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.SDS of cas: 4783-68-0