Synthesis, anti-tumour activity, and mechanism of benzoyl hydrazine Schiff base-copper complexes was written by Chen, Meixu;Chen, Xin;Huang, Guidong;Jiang, Yanlin;Gou, Yi;Deng, Jungang. And the article was included in Journal of Molecular Structure in 2022.COA of Formula: C12H9NO This article mentions the following:
Four new complexes of Cu(II) coordinated to a benzoyl hydrazine Schiff base-[Cu(L1)Cl] (C1), [Cu(L1)Py] (C2), [Cu(L2)NO3] (C3), [Cu(L3)NO3] (C4) were synthesized and characterized. X-ray crystallog. results indicated that all complexes had four-coordinated Cu centers. The mol. structures of the complexes were altered by linking the Ph or pyridyl group with the ligand branch or by attaching a 2nd ligand (Py, pyridine) to the Cu center. The IC50 values of the four complexes acting on the selected tumor cells were 2.69-16.32μM. The C1 and C2 complexes could up-regulate the expression of p21 to down-regulate the expression of cyclin D1, cyclin E, and CDK2, which caused the cell cycle to be arrested in the G1 phase. Further studies revealed that the C2 complex was able to stabilize G-quadruplex (G4) DNA structure, including that of the proto-oncogene c-kit and the Pu27 sequence situating the promoter region of c-myc, which led to the significant inhibition the expression of c-myc and c-kit. This affected the expression of downstream proteins, such as hTERT and Bcl-2, ultimately inducing apoptosis. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1COA of Formula: C12H9NO).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C12H9NO