A simple coumarin based “fluorescent On” probe for the selective detection of Al3+ along with its application in live cell imaging via AGS cell line was written by Gharami, Saswati;Aich, Krishnendu;Ghosh, Paramita;Patra, Lakshman;Murmu, Nabendu;Mondal, Tapan Kumar. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2020.Category: pyridine-derivatives This article mentions the following:
A new coumarin based fluorescent switch (HCBP) has been fabricated which displays high selective sensing towards Al3+ among other metal cations at physiol. pH. On gradual addition of Al3+ specifically, HCBP shows a brilliant “turn-on” emission enhancement of about â?3-fold with about 50 nm red shift at 481 nm in MeOH/H2O (1/1, volume/volume) solution The fluorescent switch is proven to be a reversible probe by addition of EDTA gradually into the HCBP-Al3+ solution Detection limit as well as Binding constant values have been calculated and found to be in the order of 10-9 M and 103 M-1 resp. DFT and TDDFT studies are conducted with the probe to establish a similarity between theor. and exptl. outcomes. We can also use this new fluorescent switch as a biomarker kit as it has shown a brilliant potential in the application of live cell imaging using gastric cancer cell (AGS cell). In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Category: pyridine-derivatives).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives