Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methylpiperazinyl)-containing derivatives was written by Watkins, William J.;Lemoine, Remy C.;Chong, Lee;Cho, Aesop;Renau, Thomas E.;Kuo, Bonnie;Wong, Vickie;Ludwikow, Maria;Garizi, Negar;Iqbal, Nadeem;Barnard, John;Jankowska, Renata;Singh, Rajeshwar;Madsen, Deidre;Lolans, Karen;Lomovskaya, Olga;Oza, Uma;Dudley, Michael N.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Category: pyridine-derivatives This article mentions the following:
Structure-activity relationships of a novel series of fungal efflux pump inhibitors with respect to potentiation of the activity of fluconazole against strains of Candida albicans and Candida glabrata over-expressing ABC-type efflux pumps are systematically explored. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Category: pyridine-derivatives).
3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of â?8.7 à 10â? cm3·molâ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâ? in the liquid phase and 140.4 kJ·molâ? in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives