Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists was written by Cherney, Robert J.;Nelson, David J.;Lo, Yvonne C.;Yang, Gengjie;Scherle, Peggy A.;Jezak, Heather;Solomon, Kimberly A.;Carter, Percy H.;Decicco, Carl P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Formula: C10H17NO2 This article mentions the following:
A series of cis-3,4-disubstituted piperidines was synthesized and evaluated as CC chemokine receptor 2 (CCR2) antagonists. Compound I (R = nPr) emerged with an attractive profile, possessing excellent binding (CCR2 IC50 = 3.4 nM) and functional antagonism (calcium flux IC50 = 2.0 nM and chemotaxis IC50 = 5.4 nM). Studies to explore the binding of these piperidine analogs utilized a key CCR2 receptor mutant (E291A) with compound I (R = H) and revealed a significant reliance on Glu291 for binding. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Formula: C10H17NO2).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C10H17NO2