Improvement of the synthesis process of benzobromarone was written by Huang, Li-rong;Bai, Yue-fei;Chen, Hong;Yu, Yong-qi. And the article was included in Liaoning Huagong in 2014.Synthetic Route of C5H6ClN This article mentions the following:
Friedel-Crafts acylation of 2-ethylbenzofuran with 4-methoxybenzoyl chloride was carried out in dichloromethane or chloroform, then demethylation of the product and pyridine hydrochloride was carried out, at last benzobromarone was obtained via bromination of the product and bromide, total yield reached 55%â?0%. The process is characterized with low toxicity, good product quality and is suitable for industrial production In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Synthetic Route of C5H6ClN).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Synthetic Route of C5H6ClN