Cobalt-catalyzed C4-selective direct alkylation of pyridines was written by Andou, Takashi;Saga, Yutaka;Komai, Hirotomo;Matsunaga, Shigeki;Kanai, Motomu. And the article was included in Angewandte Chemie, International Edition in 2013.SDS of cas: 27876-24-0 This article mentions the following:
A catalyst for the atom-economical C4-selective direct alkylation of pyridines is developed. A catalytic amount of CoBr2 in combination with LiBEt3H gave branched adducts from styrene derivatives, and linear adducts from aliphatic alkenes. The high catalyst turnover numbers (up to 3440; s/c = 4000) observed in the reaction with styrene are noteworthy. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0SDS of cas: 27876-24-0).
4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·molâ? in pyridine vs. 150 kJ·molâ? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. SDS of cas: 27876-24-0