Synthesis of phenoxypyridines under phase transfer catalysis conditions was written by Abele, E.;Gol’dberg, Yu. Sh.;Gavars, M.;Gaukhman, A. P.;Shimanskaya, M. V.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1988.Quality Control of 2-Phenoxypyridine This article mentions the following:
Reaction of halopyridines with PhOM (M = Na, K) in a two-phase liquid-solid catalytic system gave phenoxypyridine. With polyhalopyridines, substitution occurred at the α- and γ-positions. Reaction of o-(KO)2C6H4 with 2,3,5,6-tetrabromopyridine gave azaphenoxane I. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Quality Control of 2-Phenoxypyridine).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·molâ? in pyridine vs. 150 kJ·molâ? in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of 2-Phenoxypyridine