Comparison of Mainstream Smoke Composition from CR20 Resin Filter and Empty-Cavity Filter Cigarettes by Headspace SPME Coupled with GC×GC TOFMS and Chemometric Analysis was written by Brokl, Michal;Morales, Valle;Bishop, Louise;Wright, Christopher G.;Liu, Chuan;Focant, Jean-Francois;Nicol, James;McAdam, Kevin G.. And the article was included in Beitraege zur Tabakforschung International in 2018.Application In Synthesis of 2-Isopropylpyridine This article mentions the following:
Summary : A previously established method based on headspace solidphase microextraction (HS-SPME) and comprehensive two-dimensional gas chromatog. (GC×GC) coupled to time-of-flight mass spectrometry (TOFMS) has been used to evaluate and compare the profiles of semi-volatile compounds present in mainstream tobacco smoke particulate matter trapped on glass fiber filters for two types of cigarettes differing only in filter design. In the first cigarette, the filter cavity contained approx. 60 mg of a weakly basic macroporous polystyrene resin crosslinked with divinyl benzene and with surface amine functionality (CR20), whereas in the second cigarette, it was empty. Relative quant. anal., chem. identification, and chem. grouping allowed the use of both parametric and non-parametric analyses to identify differences in the chem. composition of the smokes from these cigarettes. The anal. demonstrated that in addition to the selective partial removal of volatile carbonyls and HCN demonstrated previously, CR20 selectively, but incompletely removed 316 compounds from the particulate phase of cigarette smoke, mainly aryl and aromatic hydrocarbons as well as other more volatile species. In contrast, the relative proportion of amines, hydroxylated aromatic compounds and less volatile species was increased in the smoke from the cigarette containing CR20 in the filter. Our findings show that high resolution GC techniques combined with mass spectrometry and chemometric approaches are powerful tools for deconvoluting the complexity of combustion aerosols, as well as helping to identify changes in chem. composition resulting from modifications to cigarette designs. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Application In Synthesis of 2-Isopropylpyridine).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application In Synthesis of 2-Isopropylpyridine