Synthesis and fungicidal activity of novel oxathiapiprolin derivatives was written by Ding, Chengrong;Pan, Yayun;Yin, Xu;Tan, Chengxia;Wang, Xuedong. And the article was included in Youji Huaxue in 2019.Computed Properties of C11H20N2O2S This article mentions the following:
In order to explore the structure of lead compounds with biol. activities, using oxathiapiprolin as a template, sixteen oxathiapiprolin derivatives I [R = Me, cyclopropyl, 2,6-di-ClC6H3; R1 = H, Ph, 2-FC6H4, etc.] were designed and synthesized to study the influences of substituent to the fungicidal activity. All the structures I were confirmed by 1H NMR, 13C NMR and HRMS. Preliminary bioassay showed that the target compounds I generally had fungicidal activitives in vitro at a concentration of 100μg/mL, the fungicidal activities of compounds I [R = cyclopropyl; R1 = 2-FC6H4] against F. graminearum was 60%, the fungicidal activities of six target compounds against D. mali were 70%, the fungicidal activities of four target compounds against Phytophthora infestans were 50%, and the fungicidal activities of I [R = Me; R1 = 3-MeC6H4] against B. cinerea was 75%. In addtion, the fungicidal activities of the target compounds aganist Diplocarpon mali and Botrytis cinerea at 100μg/mL were higher to azoxystrobin at 50μg/mL. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Computed Properties of C11H20N2O2S).
tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Computed Properties of C11H20N2O2S