A research of basic structure of hypoglycemic agent from (-)-multiflorine as a lead compound was written by Kubo, Hajime. And the article was included in Hoshi Yakka Daigaku Kiyo in 2006.Electric Literature of C7H9NO This article mentions the following:
(-)-Multiflorine, a member of Lupin alkaloids, has been known to have a hypoglycemic activity against streptozotocine-induced diabetic mice. Therefore, this research aimed at a searching of basic structure of hypoglycemic agent, (-)-multiflorine as a lead compound It appears that double bond(s) in the A-B ring system of multiflorine influence hypoglycemic potency. Among the tricyclic compounds, N-H and N-Me compounds had significant hypoglycemic effect the same as multiflorine had. It was suspected that the D-ring in (-)-multiflorine was not necessary for appearance of hypoglycemic effect and small substituted groups was influence on strength of hypoglycemic effect. The position of the oxo-group in A-B ring system of cause hypoglycemic effect but showed no acute the toxicity. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Electric Literature of C7H9NO).
4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Electric Literature of C7H9NO