Liang, Qianqian et al. published their research in Journal of Medicinal Chemistry in 2022 | CAS: 175205-82-0

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 175205-82-0

Discovery of Potent and Selective Transient Receptor Potential Vanilloid 1 (TRPV1) Agonists with Analgesic Effects In Vivo Based on the Functional Conversion Induced by Altering the Orientation of the Indazole Core was written by Liang, Qianqian;Qiao, Zhen;Zhou, Qiqi;Xue, Dengqi;Wang, KeWei;Shao, Liming. And the article was included in Journal of Medicinal Chemistry in 2022.Related Products of 175205-82-0 This article mentions the following:

Reported the synthesis of N-indazole-4-aryl piperazine carboxamide I[R1 = H, Me; R = 3-MeC6H5, 5-ClC6H5, 3-BrC6H5 etc.] analogs as TRPV1 modulators. The structure-activity relationship (SAR) revealed that substituting indazole at the 5-/6-position leads to TRPV1 agonism, whereas the 4- and 7-positions of indazole obtain mild antagonism and loss of activity, resp. The whole-cell clamp patch assay shows that I[R = H; R1 = 2,3-diClC6H5] a potent and selective TRPV1 agonist and it relieves inflammatory and thermal pain by desensitizing the native TRPV1 current in the dorsal root ganglion (DRG) in mice. Addnl., site-directed mutagenesis combined with mol. docking shows an important hydrogen interaction between Arg557 and the indazole of comp. I[R = H; R1 = 2,3-diClC6H5]. Taken together, our findings provided insight into TRPV1 agonism-antagonism conversion based on the interaction between indazole and Arg557, which provided a strategy to obtain new TRPV1 agonists by structural modification of antagonists. Compound I[R = H; R1 = 2,3-diClC6H5] used as a lead compound for further optimization. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Related Products of 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem