Antifungal characteristics of N,N’-hexamethylenebis (4-carbamoyl-1-decylpyridinium bromide) was written by Okazaki, Kiyo;Yoshida, Munehiro;Mayama, Mari;Shirai, Akihiro;Maeda, Takuya;Nagamune, Hideaki;Kourai, Hiroki. And the article was included in Biocontrol Science in 2006.Application In Synthesis of 1-Dodecylpyridin-1-ium bromide This article mentions the following:
A bis-quaternary ammonium compound (bis-QAC), N,N’-hexamethylenebis(4-carbamoyl-1-decylpyridinium bromide) (D-38), exhibited a wide antifungal spectrum and a strong activity against sixteen strains of fungi including nine strains isolated from various kinds of food. The antifungal activity was higher than that of N-dodecylpyridinium iodide, a typical mono-QAC, and that of the commonly used fungicide, 2-(4-thiazolyl) benzimidazole. The activity of D-38, however, was comparatively low when it was measured by the agar dilution method. It is considered that the hydrophobic D-38 mols., having two long alkyl chains, interacted with the agar medium, and therefore showed lower activity results. On the other hand, the activity of D-38 against Aspergillus niger IFO 6342 was not significantly influenced by temperature, pH and the initial spore concentration These results indicate that bis-QACs can exhibit a high antifungal activity whether or not the environmental conditions change. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Application In Synthesis of 1-Dodecylpyridin-1-ium bromide).
1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application In Synthesis of 1-Dodecylpyridin-1-ium bromide