Easy and efficient SNAr reactions on halopyridines in solvent free conditions was written by Loupy, Andre;Philippon, Noelle;Pigeon, Philippe;Galons, Herve. And the article was included in Heterocycles in 1991.Related Products of 4783-68-0 This article mentions the following:
Solid-liquid phase transfer catalysis without added solvent efficiently promotes SNAr reactions on 2-fluoro-, 2-chloro-, and 2-bromopyridines with a variety of anionic nucleophiles (from PhOH, PHCH2OH, Ph2CHCN, PhCH2CN, PhCHMeCN) generated in situ. This methodol. gives access to substituted pyridines I (Nu = PhO, PhCH2O, Ph2CCN, etc.) under very simplified conditions depending on halide nature. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Related Products of 4783-68-0).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 4783-68-0