Aerobic Pd-Catalyzed sp3 C-H Olefination: A Route to Both N-Heterocyclic Scaffolds and Alkenes was written by Stowers, Kara J.;Fortner, Kevin C.;Sanford, Melanie S.. And the article was included in Journal of the American Chemical Society in 2011.Category: pyridine-derivatives This article mentions the following:
This communication describes a new method for the Pd/polyoxometalate-catalyzed aerobic olefination of unactivated sp3 C-H bonds. Nitrogen heterocycles, particularly pyridines, serve as directing groups, and air is used as the terminal oxidant. The products undergo reversible intramol. Michael addition, which protects the monoalkenylated product from overfunctionalization. Hydrogenation of the Michael adducts provides access to bicyclic nitrogen-containing scaffolds that are prevalent in alkaloid natural products. Addnl., the cationic Michael adducts undergo facile elimination to release α,β-unsaturated olefins, which can be further elaborated via C-C and C-heteroatom bond-forming reactions. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Category: pyridine-derivatives).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Category: pyridine-derivatives