Nickel-Catalyzed Formal Aminocarbonylation of Unactivated Alkyl Iodides with Isocyanides was written by Huang, Wenyi;Wang, Yun;Weng, Yangyang;Shrestha, Mohini;Qu, Jingping;Chen, Yifeng. And the article was included in Organic Letters in 2020.Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:
Herein, disclosed a Ni-catalyzed formal aminocarbonylation of primary and secondary unactivated aliphatic iodides with isocyanides to afford alkyl amide, e.g., I, which proceeded via the selective monomigratory insertion of isocyanides with alkyl iodides, subsequent β-hydride elimination, and hydrolysis process. The reaction featured wide functional group tolerance under mild conditions. Addnl., the selective, one-pot hydrolysis of reaction mixture under acid conditions allowed for expedient synthesis of the corresponding alkyl carboxylic acid. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate