19F- and 18F-arene deoxyfluorination via organic photoredox-catalysed polarity-reversed nucleophilic aromatic substitution was written by Tay, Nicholas E. S.;Chen, Wei;Levens, Alison;Pistritto, Vincent A.;Huang, Zeng;Wu, Zhanhong;Li, Zibo;Nicewicz, David A.. And the article was included in Nature Catalysis in 2020.Recommanded Product: 51834-97-0 This article mentions the following:
Nucleophilic aromatic substitution (SNAr) is routinely used to install 19F- and 18F- in aromatic mols., but it is typically limited to electron-deficient arenes due to kinetic barriers associated with C-F bond formation. A polarity-reversed photoredox-catalyzed arene deoxyfluorination that operates via cation-radical-accelerated SNAr enables the fluorination of electron-rich arenes 4-ClC6H4OR (R = 4-phenylphenyl, 3-methoxypyridin-2-yl, 2,4-bis(tert-butoxy)pyrimidin-5-yl, 4-[(2S)-2-([(tert-butoxy)carbonyl]amino)-3-methoxy-3-oxopropyl]benzen-1-yl, etc.) with 19F- and 18F- under mild conditions, and thus complements the traditional arene polarity requirements necessary for SNAr-based fluorination. The utility of radiofluorination strategy is highlighted by short reaction times, compatibility with multiple nucleofuges and high radiofluorination yields 18FR, especially that of an important cancer positron emission tomog. agent [18F]5-fluorouracil. Taken together, fluorination approach enables the development of fluorinated 19FR and radiofluorinated compounds 18FR that can be difficult to access by classical SNAr strategies, with the potential for use in the synthesis and discovery of positron emission tomog. radiopharmaceuticals. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0Recommanded Product: 51834-97-0).
5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 51834-97-0