Indolizine synthesis via copper-catalyzed cyclization of gem-difluoroalkenes and 2-(pyridin-2-yl)acetate derivatives was written by Lu, Chuan-Jun;Yu, Xin;Chen, Yu-Ting;Song, Qing-Bao;Wang, Hong. And the article was included in Organic Chemistry Frontiers in 2020.Application of 917023-06-4 This article mentions the following:
A novel and versatile approach to construct substituted indolizines I (R = H, 6-Br; Ar = Ph, 3,4-dimethoxyphenyl, thiophen-2-yl, (3E)-4-phenylbut-3-en-1-yl, etc.) through copper-catalyzed coupling cyclization of 2-(pyridin-2-yl)acetate II (R1 = C(O)OMe, C(O)OEt, C(O)Oi-Pr, C(O)Me) with gem-difluoroalkenes ArCH=C(F)2 has been developed. This method takes advantage of the cleavage of C-F bonds, providing a straightforward and efficient access to a variety of bisubstituted indolizine derivatives I in moderate to good yields with brilliant functional group compatibility. In the experiment, the researchers used many compounds, for example, Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4Application of 917023-06-4).
Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application of 917023-06-4