Facilitating Rh-Catalyzed C-H Alkylation of (Hetero)arenes and 6-Arylpurine Nucleosides (Nucleotides) with Electrochemistry was written by Yang, Qi-Liang;Liu, Ying;Liang, Lei;Li, Zhi-Hao;Qu, Gui-Rong;Guo, Hai-Ming. And the article was included in Journal of Organic Chemistry in 2022.Safety of 2-(m-Tolyl)pyridine This article mentions the following:
An electrochem. approach to promote the ortho C-H alkylation of (hetero)arenes via rhodium catalysis under mild conditions was described. This approach features mild conditions with high levels of regio- and monoselectivity that tolerated a variety of aromatic and heteroaromatic groups and offered a widely applicable method for late-stage diversification of complex mol. architectures including tryptophan, estrone, diazepam, nucleosides and nucleotides. Alkyl boronic acids, esters and alkyl trifluoroborates were demonstrated as suitable coupling partners. The isolation of key rhodium intermediates and mechanistic studies provided strong support for a rhodium(III/IV or V) regime. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Safety of 2-(m-Tolyl)pyridine).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 2-(m-Tolyl)pyridine