Catalytic hydration of pyridinecarbonitriles in the presence of bis(ethylenediamine)copper(II) chloride dihydrate and copper(II) chloride dihydrate was written by Watanabe, Kenichi;Murayama, Kiyoshi. And the article was included in Bulletin of the Chemical Society of Japan in 1974.SDS of cas: 1620-76-4 This article mentions the following:
Spectrophotometric studies on the catalytic hydration of 2-pyridine-carbonitrile derivatives in the presence of the title catalysts under nearly neutral conditions revealed that the products are the amides. The hydration of the nitrile group was influenced by electronic and steric effects. Selective hydration of the nitrile group in the α-position was observed with dinitriles. The selectivity was applied to hydrolysis of nitriles to carboxylic acids. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4SDS of cas: 1620-76-4).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.SDS of cas: 1620-76-4