Reaction of pyridine 1-oxides with isocyanates: Structure of the intermediates. Rationalization of rearrangements of six-membered heteroaromatic N-oxide derivatives was written by Abramovitch, Rudolph A.;Shinkai, Ichiro;Van Dahm, Richard. And the article was included in Journal of Heterocyclic Chemistry in 1976.Recommanded Product: 3,5-Dimethylpyridine 1-oxide This article mentions the following:
Structure I (R = H, Br) claimed by Hisano, Matsuoka, and Ichikawa (1974) to be obtained from the reaction of 3,5-lutidine 1-oxide with 4-RC6H4NCO was determined to be II obtained by a rearrangement supported by MINDO/2′ calculations on relative heats of formation of analogous compounds Reduction and NMR studies of II also confirmed this structure. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Recommanded Product: 3,5-Dimethylpyridine 1-oxide).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 3,5-Dimethylpyridine 1-oxide