Benzomorphan related compounds. V. Synthesis of thienomorphans was written by Alvarez, M.;Bosch, J.;Granados, R.;Lopez, F.. And the article was included in Journal of Heterocyclic Chemistry in 1978.Category: pyridine-derivatives This article mentions the following:
Thienomorphans, e.g. I, II, and III, were prepared via the Grewe synthesis and by the reaction of 2-cyanopyridines with 3-thienyllithium. Thieno[2,3-f]morphans were also prepared from 3-oxotetrahydrothiophene. Separation and assignment of the α- and β-diastereomeric structures by means of NMR data is reported. Some side products were isolated and their structures were confirmed on the basis of their spectral data. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Category: pyridine-derivatives).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives