RhIII-Catalyzed Olefination of 2-Aryloxy-pyridines Using 2-Pyridyloxyl as the Removable Directing Group was written by Borah, Arun Jyoti;Yan, Guobing;Wang, Lianggui. And the article was included in European Journal of Organic Chemistry in 2015.Safety of 2-Phenoxypyridine This article mentions the following:
An efficient RhIII-catalyzed trans selective ortho-olefination of 2-aryloxypyridines I (R = 2-FC6H4, 4-ClC6H4, 3-F3CC6H4, 2-H3CC6H4, etc.) has been developed. The catalytic system is very effective for olefination of differently substituted 2-aryloxypyridines with acrylates or acrylamide CH2:CHCOR1 [R1 = OCH2CH3, OCH3, N(CH3)2, etc.] and styrenes R2CH:CH2 [R2 = 2-ClC6H4, 4-(H3C)3CC6H4, naphthalen-1-yl, etc.] and exhibits broad compatibility with assorted olefinic coupling partners. Although acrylates and acrylamide give rise to trans-olefinated products II in MeOH, styrenes provided the trans products III under solvent-free reaction conditions. Interestingly, in olefinations with Et acrylate, the aryloxypyridine compound bearing keto functionality at the ortho position was found to undergo directing group cleavage to afford the olefinated phenol product 2-HO-3-H3CC6H3CH:CHC6H5 directly. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Safety of 2-Phenoxypyridine).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of 2-Phenoxypyridine