Trimethylsilanol as a leaving group; III. A simple one-step conversion of aromatic heterocyclic N-oxides to α-cyano aromatic N-heterocycles was written by Vorbrueggen, Helmut;Krolikiewicz, Konrad. And the article was included in Synthesis in 1983.Recommanded Product: 1620-76-4 This article mentions the following:
Heterocyclic N-oxides such as pyridine or quinoline N-oxides were treated with Me3SiCN in the presence of Et3N in MeCN to give α-cyano heterocycles. The strong affinity of the hard Me3Si group for the hard N-oxide moiety and the soft CN group for the adjacent soft α-C atom was apparently the driving force for the selective α-addition of Me3SiCN to the heterocyclic N-oxide, followed by elimination of Me3SiOH as a leaving group. Thus, pyridine N-oxide added Me3SiCN to give 80% 2-cyanopyridine. Among the ∼10 other compounds similarly prepared were 2-cyano-4-methylpyridine, 2-cyano-3-hydroxypyridine and 2-cyanoquinoline. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Recommanded Product: 1620-76-4).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 1620-76-4