Synthesis of m-Alkylphenols via a Ruthenium-Catalyzed C-H Bond Functionalization of Phenol Derivatives was written by Li, Gang;Gao, Panpan;Lv, Xulu;Qu, Chen;Yan, Qingkai;Wang, Ya;Yang, Suling;Wang, Junjie. And the article was included in Organic Letters in 2017.Quality Control of 2-Phenoxypyridine This article mentions the following:
In the presence of [RuCl2(p-cymene)]2 and 1-adamantanecarboxylic acid, aryl 2-pyridinyl ethers underwent regioselective alkylation with secondary and tertiary alkyl bromides mediated by K2CO3 in benzene to provide m-alkylaryl 2-pyridinyl ethers in 33-73% yields; N-methylation of the pyridine moiety with Me triflate followed by hydrolysis yielded m-alkylated phenols such as 3-tert-butylphenol in 74-82% yields. The method was used to prepare the pesticide etoxazole via 3-tert-butylphenol. A (p-cymene)ruthenium complex of 2-phenoxypyridine was prepared and underwent regioselective alkylation to give 3-(3-pentyl)phenyl 2-pyridinyl ether under the standard reaction conditions; addition of TEMPO, BHT, or benzoquinone inhibited the reaction. The structure of the (p-cymene)ruthenium complex of 2-phenoxypyridine was determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Quality Control of 2-Phenoxypyridine).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 2-Phenoxypyridine