Recyclable Pd(II)complex catalyzed oxidative sp2 C-H bond acylation of 2-aryl pyridines with toluene derivatives was written by Perumgani, Pullaiah C.;Parvathaneni, Sai Prathima;Keesara, Srinivas;Mandapati, Mohan Rao. And the article was included in Journal of Organometallic Chemistry in 2016.COA of Formula: C12H11N This article mentions the following:
A recyclable polymer-anchored Pd(II) complex C was synthesized and characterized using different spectroscopic techniques. In addition the catalytic efficiency of the Pd (II) complex C was evaluated for ortho-acylation of 2-aryl pyridines with toluene derivatives to form aryl ketones via cross dehydrogenative coupling. In this catalytic process toluene acts as an effective coupling partner upon sp3 C-H bond oxidation for sp2 C-H bond acylation of 2-aryl pyridines in the presence of Pd(II)/TBHP system on water. Furthermore, the catalyst C was highly stable and could be easily recovered and reused for four cycles with no significant decrease in its activity and selectivity. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9COA of Formula: C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C12H11N