Effect of substituents on the basicity of pyridines in an apolar medium was written by Laurence, C.;Lucon, M.. And the article was included in Canadian Journal of Chemistry in 1976.Related Products of 4783-68-0 This article mentions the following:
The frequency v(OH…N) of methanol complexes with substituted pyridines appears to be a sensitive detector of substituent effects on the basicity of pyridines in an apolar medium. The coefficients ρI and ρR, which respond to I and R effects and which are obtained from the Taft-Ehrenson equation, agree with those found for the pKa of pyridinium ions for the three substitution positions. Those values which diverge are explained by the much greater electron attracting power of the zonium group compared to that of the aza group. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Related Products of 4783-68-0).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Related Products of 4783-68-0