Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope was written by Robin, Aelig;Kohler, Valentin;Jones, Alison;Ali, Afruja;Kelly, Paul P.;O’Reilly, Elaine;Turner, Nicholas J.;Flitsch, Sabine L.. And the article was included in Beilstein Journal of Organic Chemistry in 2011.Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:
A high-throughput screening protocol for evaluating chimeric, self-sufficient P 450 biocatalysts and their mutants against a panel of substrates was developed, leading to the identification of a number of novel biooxidation activities. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate