Regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide under metal-free conditions was written by Liu, Xiang;Song, Dan;Zhang, Zemin;Lin, Jiatong;Zhuang, Canzhan;Zhan, Haiying;Cao, Hua. And the article was included in Organic & Biomolecular Chemistry.Safety of 4-Methoxy-2-methylpyridine This article mentions the following:
An efficient and straightforward metal-free regioselective C-H dithiocarbamation of indolizines with tetraalkylthiuram disulfide has been described. A series of indolizine-dithiocarbamate derivatives, e.g., I (R1 = H, 8-Br, 6-Et, 7-MeO, etc., R2 = Ph, 3,4-Cl2C6H3, 2-furyl, etc.), were easily accessed in moderate to good yields with a broad scope. In addition, imidazo[1,2-a]pyridines II (R1 = H, 7-Me, R2 = Ph, 3-FC6H4, 3-MeOC6H4) were also well tolerated to afford diverse imidazoheterocycle-dithiocarbamate products, which are expected to be utilized for drug discovery. Of note, the reaction could be readily scaled up, and shows its practical value in organic synthesis. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Safety of 4-Methoxy-2-methylpyridine).
4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of 4-Methoxy-2-methylpyridine