Kinetic study on the conversion of pyridine- and quinolinecarboxylic acids to the corresponding trichloromethyl compounds was written by Takahashi, Kazuyuki;Takeda, Koichi;Mitsuhashi, Keiryo. And the article was included in Journal of Heterocyclic Chemistry in 1978.Application of 3718-65-8 This article mentions the following:
The apparent 2nd order rate constant of the conversion of substituted picolinic and quinaldinic acids to the corresponding trichloromethylpyridines and quinolines by treatment with PCl5 in refluxing SOCl2 was measured. The logarithms of the rate constants (log k) are linear with the basicities (pKa) of the unsaturated ring nitrogens in the substrates. The reaction constant ρ was estimated In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Application of 3718-65-8).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 3718-65-8