Inducing Axial Chirality in a Supramolecular Catalyst was written by Wenz, Katharina Marie;Leonhardt-Lutterbeck, Guenter;Breit, Bernhard. And the article was included in Angewandte Chemie, International Edition in 2018.Computed Properties of C5H3Br2NO This article mentions the following:
A new type of ligand, which is able to form axially chiral, supramol. complexes was designed using DFT calculations Two chiral monomers, each featuring a covalently bound chiral auxiliary, form a bidentate phosphine ligand with a twisted, hydrogen-bonded backbone upon coordination to a transition metal center which results in two diastereomeric, tropos complexes. The ratio of the diastereomers in solution is very temperature- and solvent-dependent. Rhodium and platinum complexes were analyzed through a combination of NMR studies, ESI-MS measurements, as well as UV-VIS and CD spectroscopy. The chiral self-organized ligands were evaluated in the rhodium-catalyzed asym. hydrogenation of α-dehydrogenated amino acids and resulted in good conversion and high enantioselectivity. This research opens the way for new ligand designs based on stereocontrol of supramol. assemblies through stereodirecting chiral centers. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Computed Properties of C5H3Br2NO).
2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Computed Properties of C5H3Br2NO