NMR studies of picolyl-type carbanions. VIII. Anions produced by reactions of alkyl-substituted pyridines with butyllithium was written by Konishi, Kazuyori;Matsumoto, Hiroshi;Saito, Katsuhiro;Takahashi, Kensuke. And the article was included in Bulletin of the Chemical Society of Japan in 1985.Product Details of 644-98-4 This article mentions the following:
1H and 13C NMR spectra are reported for anions produced from methyl-, ethyl- and isopropylpyridines in THF. Two kinds of anions are formed concomitantly by Li-proton exchange and BuLi addition with 2-ethyl-, 2-isopropyl-, 4-methyl- and 4-ethylpyridines. The former reaction tends to occur at the substituent bonded to the position adjacent to N, and the latter occurs at an unsubstituted position adjacent to N. In the anions formed by the exchange from 2- and 4-ethylpyridines, a specific ring proton is coupled to the α-C atom, and, further, the o– or m-protons (or -C atoms) in the latter anion are nonequivalent at room temperature The α-carbons in these anions are virtually sp2-hybridized. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Product Details of 644-98-4).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Product Details of 644-98-4