Regioselective cyanation of 3-substituted pyridine 1-oxides was written by Fife, Wilmer K.. And the article was included in Heterocycles in 1984.Application of 89809-65-4 This article mentions the following:
N-Oxides I (R = H, Me, OMe, OH, Cl, cyano, CO2Me) were converted to mixtures of nitriles II and III. I (R = Me) was treated with Me3SiCN and Me2NCOCl in CH2Cl2 to give 90% II (R = Me) and 10% III (R = Me). In the experiment, the researchers used many compounds, for example, Methyl 6-Cyanopyridine-3-carboxylate (cas: 89809-65-4Application of 89809-65-4).
Methyl 6-Cyanopyridine-3-carboxylate (cas: 89809-65-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application of 89809-65-4