2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties was written by Charoensutthivarakul, Sitthivut;David Hong, W.;Leung, Suet C.;Gibbons, Peter D.;Bedingfield, Paul T. P.;Nixon, Gemma L.;Lawrenson, Alexandre S.;Berry, Neil G.;Ward, Stephen A.;Biagini, Giancarlo A.;O’Neill, Paul M.. And the article was included in MedChemComm in 2015.Application of 131747-45-0 This article mentions the following:
A series of 2-pyridylquinolones has been prepared in 5-7 steps and through lead optimization, antimalarial activity as low as 12 nM against Plasmodium falciparum (Pf) has been achieved. Compared with previous analogs in this series, selected mols. have improved solubility, a reduced potential for off-target toxicity and improved metabolic stability profiles. Docking studies performed with a homol. model of the Pfbc1 complex target demonstrate a key role for the Tyr16 residues in the recognition of highly active quinolone based inhibitors. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Application of 131747-45-0).
(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 131747-45-0