Mechanism of the electrophilic substitution of heteroaromatic compounds. X. Acid-catalyzed hydrogen exchange at the α-, β-, and γ-positions of substituted pyridine 1-oxides was written by Bean, Gerritt P.;Brignell, Peter J.;Johnson, Colin David;Katritzky, Alan R.;Ridgewell, Brian J.;Tarhan, H. O.;White, Anthony Mallinson. And the article was included in Journal of the Chemical Society [Section] B: Physical Organic in 1967.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:
H exchange reactions on 2,4,6-trimethyl- and 2,6-dimethylpyridine 1-oxide in the 3-position proceed on the conjugate acids. H exchange of 3,5-dimethylpyridine 1-oxide by contrast proceeds on the free base in the 2-, 4-, and 6-positions, while 3-hydroxypyridine 1-oxide also reacts on the free base, in the 2-position. For 3,5-dimethoxypyridine 1-oxide (I), changeover from 2- and 6-position exchange on the free base to exchange at the same positions on the conjugate acid is observed with increasing acidity. The orientations of acid-catalyzed H exchange and nitration in pyridine 1-oxides are compared and discussed. 20 references. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Safety of 3,5-Dimethylpyridine 1-oxide