Yang, Qiang et al. published their research in Organic Process Research & Development in 2018 | CAS: 175205-82-0

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. COA of Formula: C6H3BrF3N

Safety Evaluation of the Copper-Mediated Cross-Coupling of 2-Bromopyridines with Ethyl Bromodifluoroacetate was written by Yang, Qiang;Cabrera, Pablo J.;Li, Xiaoyong;Sheng, Min;Wang, Nick X.. And the article was included in Organic Process Research & Development in 2018.COA of Formula: C6H3BrF3N This article mentions the following:

Potential safety hazards associated with Cu-mediated cross-coupling of 2-bromopyridines with Et bromodifluoroacetate were evaluated. An accelerating rate calorimetry thermal stability evaluation of the post-reaction mixture of 50.6 mmol 2-bromopyridine with 1.3 equivalent Et bromodifluoroacetate in the presence of 2.1 equivalent Cu in 40 mL DMSO indicated a significant decomposition event with a 115.5° onset temperature, which was significantly lower than that of neat DMSO. The reaction mixture in N,N-dimethylformamide did not display any exothermic decomposition up to 400° using differential scanning calorimetry. Reaction calorimetry evaluation of this reaction in DMSO showed a heat output (ΔH) of -13.5 kJ and an adiabatic temperature rise (ΔTad) of 129.5°, resulting in a maximum temperature of a synthesis reaction (MTSR) of 189.5°. The predicted heat of reaction using d. functional theory with BLYP functional agreed well with exptl. data. Scope studies with a multiple substituted 2-bromopyridines showed similar ΔH and ΔTad magnitudes vs. 2-bromopyridine when reacted at the same concentration In all studied cases, MTSR was significantly higher than the onset temperature of reaction mixture decomposition, indicating that in the absence of active cooling, the system could quickly trigger decomposition of the reaction mixture and result in a runaway reaction. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0COA of Formula: C6H3BrF3N).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. COA of Formula: C6H3BrF3N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem