New Synthetic Routes to 3-, 5-, and 6-Aryl-2-chloropyridines was written by Church, Robert;Trust, Ronald;Albright, J. Donald;Powell, Dennis. And the article was included in Journal of Organic Chemistry in 1995.Application In Synthesis of 5-Phenylpyridin-2-ol This article mentions the following:
The efficient synthesis of 3-, 5-, and 6-aryl-2-chloropyridines, e.g., I (R1 = H, 3-pyridinyl, SO2Ph, etc., R2 = H, 3-F3CC6H4, 2,4-Cl2C6H3, 4-Ph, etc., R3 = H, Ph, 3-pyridinyl, etc.), via the facile preparation of 5-(dimethyamino)aryl-substituted pentadienyl nitriles and cyclization with hydrochloric acid is described. This approach allows for the introduction of other electron-withdrawing substituents on the pyridine ring as well as the preparation of the desired unsubstituted arylpyridines. Some differences in the rates of cyclization of the pentadienyl nitriles as well as the yields of chloropyridines were observed that depended on the position and degree of substitution in the aryl substituent. The arylpentadienyl nitriles Me2NCH:CCHCH:CArCN (Ar = 3-pyridinyl, 3-F3CC6H4, 3-MeOC6H4, Ph) could also be converted directly into the corresponding 2-aminopyridines. In the experiment, the researchers used many compounds, for example, 5-Phenylpyridin-2-ol (cas: 76053-45-7Application In Synthesis of 5-Phenylpyridin-2-ol).
5-Phenylpyridin-2-ol (cas: 76053-45-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of 5-Phenylpyridin-2-ol