Copper(II) Catalyzed C-H Alkoxylation of 2-Phenylpyridines with Aliphatic Diols was written by Xiao, Yan;Li, Juan;Liu, Yajun;Wang, Shuo;Zhang, Hui;Ding, Huaiwei. And the article was included in European Journal of Organic Chemistry in 2018.Formula: C12H11N This article mentions the following:
A very simple copper(II) catalyzed C-O coupling reaction of 2-phenylpyridines and aliphatic diols was achieved by using a strategy of C-H functionalization. A series of aroxylethanols are easily obtained with the yields of 30-67 %. Various functional groups, as well as different length of aliphatic diols are well tolerated in the developed catalytic system. This protocol features a simple reaction system, economical catalyst and good regioselectivity. In addition, a “one-pot” synthesis of 2-phenylpyridines was developed. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Formula: C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Formula: C12H11N