Use of dipolar species under phase-transfer catalysis. Part 1. 1,3-Dipolar cycloaddition in a two-phase system was written by Alvarez-Builla, Julio;Quintanilla, M. Gloria;Abril, Catalina;Gandasegui, M. Teresa. And the article was included in Journal of Chemical Research, Synopses in 1984.COA of Formula: C7H7ClN2 This article mentions the following:
Eleven indolizines were prepared in 18-82% yield by 1,3-dipolar cycloaddition of pyridinium ylides with RCCCO2Me (R = MeO2C, Ph) in a 2-phase system. Addition of MeO2CCCCO2Me to N-(methoxycarbonylmethyl)pyridinium chloride and KOH, supported on alumina (1:1) suspended in MeCN, at room temperature for >18 h, followed by dehydrogenation with 5% Pd-C at reflux for 4 h gave 44% indolizine I. Phase-transfer catalysts did not significantly improve the yields. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3COA of Formula: C7H7ClN2).
1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C7H7ClN2