Original synthesis of radiolabeling precursors for batch and on resin one-step/late-stage radiofluorination of peptides was written by Richard, Mylene;Specklin, Simon;Roche, Melanie;Hinnen, Francoise;Kuhnast, Bertrand. And the article was included in Chemical Communications (Cambridge, United Kingdom).Reference of 3939-12-6 This article mentions the following:
Radiolabeling of peptides with fluorine-18 is hurdled by their chem. sensitivity and complicated processes. Original triflyl-pyridine intermediates afforded ammonium precursors that were radiolabeled at low temperature From that study, a generic tag has been designed to allow a simple one-step/late-stage radiolabelling of peptides. The strategy has been transposed to an automated “on-resin” radiolabelling. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Reference of 3939-12-6).
6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of 3939-12-6