Structures of substituted di-aryl-1,3,4-oxadiazole derivatives: 2,5-bis(pyridyl)- and 2,5-bis(aminophenyl)-substitution was written by Emmerling, Franziska;Orgzall, Ingo;Reck, Guenter;Schulz, Burkhard W.;Stockhause, Sabine;Schulz, Burkhard. And the article was included in Journal of Molecular Structure in 2006.Synthetic Route of C12H8N4O This article mentions the following:
Crystal structures of four different di-aryl-1,3,4-oxadiazole compounds (aryl = 2-pyridyl-, 3-pyridyl-, 2-aminophenyl-, 3-aminophenyl-) are determined Crystallization of di(2-pyridyl)-1,3,4-oxadiazole yielded monoclinic and triclinic polymorphs. The structures are characterized by the occurrence of π-π interactions. Addnl., in case of the aminophenyl compounds intra- as well as intermol. hydrogen bonds are found that influence the packing motif as well. Since these mols. are often used as ligands in metal-organic complexes similarities and differences of the mol. conformation between the mols. in the pure crystals and that of the ligands in the complexes are discussed. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Synthetic Route of C12H8N4O).
2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C12H8N4O