Intrinsic electrophilicity of the 4-methylsulfonyl-2-pyridone scaffold in glucokinase activators: Role of glutathione-S-transferases and in vivo quantitation of a glutathione conjugate in rats was written by Litchfield, John;Sharma, Raman;Atkinson, Karen;Filipski, Kevin J.;Wright, Stephen W.;Pfefferkorn, Jeffrey A.;Tan, Beijing;Kosa, Rachel E.;Stevens, Benjamin;Tu, Meihua;Kalgutkar, Amit S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.HPLC of Formula: 343262-51-1 This article mentions the following:
Previous studies on the in vitro metabolism of 4-alkylsulfonyl-2-pyridone-based glucokinase activators revealed a facile, non-enzymic displacement of the 4-alkylsulfonyl group by glutathione. In the present studies, a role for glutathione-S-transferases (GST) as catalysts in the desulfonylation reaction was demonstrated using a combination of human liver microsomes, human liver cytosol and human GSTs. The identification of a glutathione conjugate in circulation following i.v. administration of a candidate 4-methylsulfonyl-2-pyridone to rats confirmed the relevance of the in vitro findings. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-(methylsulfonyl)pyridine (cas: 343262-51-1HPLC of Formula: 343262-51-1).
2-Bromo-5-(methylsulfonyl)pyridine (cas: 343262-51-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 343262-51-1