Chemistry of 3-hydroxypyridine. Part 3. Synthesis of substituted 3-[fluoro(chloro)alkoxy]pyridines from halo- or amino-3-hydroxypyridines was written by Fuss, Andreas;Koch, Volker. And the article was included in Synthesis in 1990.Electric Literature of C5H3Br2NO This article mentions the following:
The nucleophilic addition of 3-hydroxypyridine to F2C:CFCF3 gave 73% 3-[(1,1,2,3,3,3-pentafluoropropyl)oxy]pyridine. The preparation of other 3-[(fluoroalkyl)oxy]pyridines from polyfluoroalkenes and hydroxpyridine derivatives is described. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Electric Literature of C5H3Br2NO).
2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Electric Literature of C5H3Br2NO