Related Products of 68963-75-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 68963-75-7, name is 4,6-Dichloropyridin-2(1H)-one. A new synthetic method of this compound is introduced below.
2,4-Dichloro-6-hydroxypyridine (696mg, 4.2mmol), 3-exo-hydroxy-8- azabicyclo[3.2.1]octane-8-carboxylic acid terf-butyl ester (965mg, 4.2mmol) and (4,4- Dimethyl-1 ,1-dioxido-1 ,2,5-thiadiazolidin-2-yl)triphenylphosphonium (4.31g, 10.5mmol) in THF (2OmL) were stirred for 16h. Ethyl acetate (5OmL) and water (2OmL) were added and the organic and aqueous layers were separated. The organic layer was dried over Na2SO4 and concentrated in vacuo. The crude material was then purified by chromatography on silica gel. Elution with 10:90 ethyl acetate:heptane afforded 3-exo-(4,6-dichloropyridin-2- yloxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid terf-butyl ester (1.29g, 3.6mmol, 82percent). M.S. (ESI) m/z: 373,375 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,68963-75-7, its application will become more common.
Reference:
Patent; N.V. ORGANON; WO2007/63071; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem