Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3222-48-8, name is 5-Cyano-2-picoline. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H6N2
To a solution of 6-methylpyridine-3-carbonitrile (10.5 g, 25.7 mmol) in MeOH (80 mL) and NHs/MeOH (20 mL, 7 M) was added Raney-Ni (2.0 g) under N2 atmosphere. The suspension was degassed in vacuo and refilled with H2. The mixture was stirred for 12 hrs at 40 C under H2 (50 psi) atmosphere. The reaction mixture was filtered and the filtrate was concentrated in vacuo to give (6-methyl-3-pyridyl)methylamine (9.5 g, compound 34b) as a light oil. 1H NMR (400 MHz, DMSO- d6) delta ppm: 8.36 (s, 1H), 7.62 (d, 7 = 8.0 Hz, 1H), 7.18 (d, / = 8.0 Hz, 1H), 3.69 (s, 2H), 2.42 (s, 3H). MS obsd. (ESI+) [(M+H)+]: 123.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3222-48-8, 5-Cyano-2-picoline.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; LIANG, Chungen; MIAO, Kun; WANG, Jianping; YUN, Hongying; ZHENG, Xiufang; (230 pag.)WO2016/180695; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem