Synthetic Route of 69872-17-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69872-17-9, name is 4-Bromo-1H-pyrrolo[2,3-c]pyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a mixture of compound 4-bromo-1H-pyrrolo[2,3-c]pyridine (D16) (20.4 g), Zn(CN)2 (12.2 g) and Zn dust (1.4 g) in DMF (300 mL) was added Pd(dppf)CI2 (8.5 g). The reaction mixture was heated to 120 0C and stirred at that temperature for 2 h. The mixture was diluted with water, extracted with EtOAc. The organic layers were washed with water and brine, dried over anhydrous Na2SO4 , evaporated and purified on column chromatography to afford 1H-pyrrolo[2,3-c]pyridine-4-carbonitrile (D17) as white solid (3.9 g). deltaH (DMSO-d6, 400MHz): 6.69 (1 H, d), 7.93 (1 H, d), 8.57 (1 H, s), 9.01 (1 H, s), 12.30 (1H, s); MS (ES): C8H5N3 requires 143; found 144.0 (M+H+)
According to the analysis of related databases, 69872-17-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; LIN, Xichen; MENG, Qinghua; ZHANG, Haibo; LI, Chengyong; WO2010/145201; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem