Electric Literature of 16879-02-0, Adding some certain compound to certain chemical reactions, such as: 16879-02-0, name is 6-Chloropyridin-2(1H)-one,molecular formula is C5H4ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16879-02-0.
Example 96 2-Chloro-N-(1 -hydroxy-cyclohexylmethyl)-5-(1 -methyl -6-oxo-1 ,6- dihydro-pyridin-2-ylamino)-benzamide96.1 6-Chloro- 1-meth yl- 1 H-p yridin-2-oneTo a suspension of 6-chloro-2-pyridinol (3 g) in acetone (1 16 mL) was added potassium carbonate (1 1.2 g) and methyl iodide (4.92 mL) and the mixture was stirred for 5h at RT. It was filtered off and the filtrate was concentrated in vacuo. The crude was purified by CC (Hept/EtOAc 8/2 to 0/1 ) to give 1 .96 g of the titled compound as a white solid.LC-MS (B): tR = 0.39 min; [M+H]+: 144.14
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16879-02-0, 6-Chloropyridin-2(1H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; WO2012/114268; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem