Electric Literature of 633328-33-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 633328-33-3, name is 3-Bromo-1H-pyrazolo[4,3-b]pyridine. A new synthetic method of this compound is introduced below.
To a stirred solution of 3-bromo-1 H-pyrazolo[4,3-b]pyridine (200 mg, 1.01 mmol) in DMF (5 mL), 3,4-dihydro- 2H-pyran (127 mg, 1.51 mmol) and a catalytic amount of pTSA were added at rt. The resulting solution was stirred at 85 C for 24h. The reaction was cooled to rt, diluted with water and extracted with EtOAc. The organic layer was washed with water and brine solution, dried over anhydrous Na2SC>4, and filtered. The resulting solution was concentrated under reduced pressure to get crude a residue that was purified by flash columnchromatography to afford the title compound (150 mg, 52.8 %).LC-MS (method 1): Rt = 2.24 min; m/z = 282.30 (M+H+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,633328-33-3, its application will become more common.
Reference:
Patent; ORYZON GENOMICS, S.A.; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; SALAS SOLANA, Jorge; (103 pag.)WO2019/110663; (2019); A1;,
Pyridine – Wikipedia,
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