Synthetic Route of 6975-44-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6975-44-6, name is Ethyl 4,6-dihydroxynicotinate, molecular formula is C8H9NO4, molecular weight is 183.16, as common compound, the synthetic route is as follows.
(Wallace, E., et.al, ibid.)’. A stirred suspension of compound ii (1.40 g, 7.67 mmol) in phosphorus (V) oxychloride (15 mL) was heated to 110C for 2.5 h with a guard tube (CaCl2) fitted. The reaction mixture was cooled to room temperature, reduced in vacuo and the resulting dark brown residue taken up in a small volume of DCM (~ 5 mL) and transferred dropwise onto a slurry of ice in water (250 mL) whilst stirring vigorously. The aqueous mixture was extracted with EtOAc (3 x 100 mL), the organic extracts combined, dried (MgS04) and evaporated to dryness to afford the crude product as an orange gum. Column chromatography (S1O2), eluting with 15: 1 Hexanes-EtOAc, afforded compound iii. (1.33 g, 6.14 mmol, 79%) as a colourless oil; [M+H]+ m/z = 220.0.
Statistics shows that 6975-44-6 is playing an increasingly important role. we look forward to future research findings about Ethyl 4,6-dihydroxynicotinate.
Reference:
Patent; BIOTA EUROPE LTD; TYNDALL, Edward Malcolm; CZAPLEWSKI, Lloyd George; FISHWICK, Colin William Gordon; YULE, Ian Andrew; MITCHELL, Jeffrey Peter; ANDERSON, Kelly Helen; PITT, Gary Robert William; WO2013/91011; (2013); A1;,
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