Adding a certain compound to certain chemical reactions, such as: 56187-37-2, 2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
200ml of toluene and 2-iodophenylboronic acid (0.21mol) were added to a clean reaction flask, then compound IV210.93g (1.06mol) was added, and then compound III327.21g (0.95mol) was slowly added, and the reaction was refluxed for 5-6h, After the reaction, cooled to room temperature, transferred to purified water, separated the solid and filtered, washed with purified water, recrystallized with ethanol, and dried under vacuum to obtain 484.55 g of cefoxidone (I), with a molar yield of 93% and a purity of 99.9 %,Maximum single impurity 0.04%
The synthetic route of 56187-37-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Liu Zhenteng; Liang Zhen; Liu Jiang; Liu Qingli; Zhang Jiwen; (6 pag.)CN110563750; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem